Dimethylaminoethanol, often abbreviated as DMAE, is a naturally occurring compound produced by the human brain and also found in certain foods such as sardines and anchovies. It’s used widely in the skincare and healthcare industry due to its potential benefits for brain health and skin appearance. In skincare products, DMAE is known to improve skin firmness and reduce the appearance of wrinkles. As a supplement, it’s believed to enhance memory and cognitive function, though research is still ongoing. Its potential for boosting neural health makes it a topic of interest in nootropic circles.

Dimethylaminoethanol (DMAE) is often called “facelift in a jar” by skin care specialists, because it helps firm and tighten the skin. With regular use DMAE will give skin a more defined, youthful appearance. DMAE has been reported by Dermatological studies to help firm and tone throat and facial skin.

References

1. DMAE – Is it Really a “Facelift-in-a-Jar”?  https://www.amaskincare.com/dmae-benefits-skin-tightening-loose-skin/
2. Grossman R. The role of dimethylaminoethanol in cosmetic dermatology. Am J Clin Dermatol. 2005;6(1):39‐47. doi:10.2165/00128071-200506010-00005
3. Uhoda I, Faska N, Robert C, Cauwenbergh G, Piérard GE. Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel. Skin Res Technol. 2002;8(3):164‐167. doi:10.1034/j.1600-0846.2002.10295.x
4. Morissette G, Germain L, Marceau F. The antiwrinkle effect of topical concentrated 2-dimethylaminoethanol involves a vacuolar cytopathology. Br J Dermatol. 2007;156(3):433‐439. doi:10.1111/j.1365-2133.2007.07681.x
5. Liu S, Chen Z, Cai X, et al. Effects of dimethylaminoethanol and compound amino acid on D-galactose induced skin aging model of rat. ScientificWorldJournal. 2014;2014:507351. doi:10.1155/2014/507351
6. Tadini KA, Campos PM. In vivo skin effects of a dimethylaminoethanol (DMAE) based formulation. Pharmazie. 2009;64(12):818‐822.
7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123624/

DMAE (Wikipedia)

Dimethylethanolamine (DMAE or DMEA) is an organic compound with the formula (CH₃)₂NCH₂CH₂OH. It is bifunctional, containing both a tertiary amine and primary alcohol functional groups. It is a colorless viscous liquid. It is used in skin care products for improving skin tone and also taken orally as a nootropic. It is prepared by the ethoxylation of dimethylamine.

Dimethylethanolamine

Names
Preferred IUPAC name 2-(Dimethylamino)ethan-1-ol
Other names deanol, dimethylaminoethanol, dimethyl ethanolamine
Identifiers
CAS Number	108-01-0 Y
3D model (JSmol)	Interactive image
Abbreviations	DMAE, DMEA
Beilstein Reference	1209235
ChEBI	CHEBI:271436 N
ChEMBL	ChEMBL1135 N
ChemSpider	13854944 N
ECHA InfoCard	100.003.221
EC Number	203-542-8
KEGG	D07777 N
MeSH	Deanol
PubChem CID	7902
RTECS number	KK6125000
UNII	2N6K9DRA24 Y
UN number	2051
CompTox Dashboard (EPA)	DTXSID2020505
InChI InChI=1S/C4H11NO/c1-5(2)3-4-6/h6H,3-4H2,1-2H3 N Key: UEEJHVSXFDXPFK-UHFFFAOYSA-N N
SMILES CN(C)CCO
Properties
Chemical formula	C4H11NO
Molar mass	89.138 g·mol−1
Appearance	Colourless liquid
Odor	Fishy, ammoniacal
Density	890 mg mL−1
Melting point	−59.00 °C; −74.20 °F; 214.15 K
Boiling point	134.1 °C; 273.3 °F; 407.2 K
log P	−0.25
Vapor pressure	816 Pa (at 20 °C)
Acidity (pKa)	9.23 (at 20 °C)
Basicity (pKb)	4.77 (at 20 °C)
Refractive index (nD)	1.4294
Pharmacology
ATC code	N06BX04 (WHO)
Hazards
GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H226, H302, H312, H314, H332
Precautionary statements	P280, P305+P351+P338, P310
Flash point	39 °C (102 °F; 312 K)
Explosive limits	1.4–12.2%
Lethal dose or concentration (LD, LC):
LD50 (median dose)	1.214 g kg−1 (dermal, rabbit) 2 g kg−1 (oral, rat)
Related compounds
Related alkanols	N-Methylethanolamine Diethylethanolamine Diethanolamine N,N-Diisopropylaminoethanol Methyl diethanolamine Triethanolamine Bis-tris methane
Related compounds	Diethylhydroxylamine
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references